My name is Yavuz Sahin and I am originally from Turkey. I have wanted to be a doctor since I was a child, but in medical school, the thought of being a scientist and discovering something useful to humanity led me to the field of genetics. That’s why I made my residency in medical genetics at Hacettepe University School of Medicine at Ankara and earned the title of specialist in Medical Genetics in 2015. I worked as a Medical Geneticist Physician at State Hospital. I established the first medical genetics laboratory in the city, and my research on neurodegenerative disorders was published in very reputable journals.
Throughout my more than eleven years in the medical genetics field, I have conducted many groundbreaking research projects that tackle problems with medical genetic care. These research projects are primarily centered around rare disorders, cancer genetics, and neurogenetic disease-related medical care.
I work on whole exome sequencing, large panels, and cancer genetics as a genetic variant scientist. These genetic tests are super important for patient-critical decisions which relate to a physician’s ability to provide proper diagnosis. That’s why variant scientists guide physicians in drug choices to treat cancer patients.
Please bear in mind that the list below is not at all exhaustive, but rather an overview of the materials engineering field.
Using ACMG criteria to interpret genetic variants to make diagnosis. You can read and learn all criteria from the publication (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544753/). This is the main guideline for analyzing patients' data.
Using online genetic databases for evaluating genetic alterations. Almost every day a new tool or database is launched. You can follow some journals (The AJHG, Bioinformatics, Nature Genetics) to be updated.
Deeply knowing that clinical symptoms of patients related to which genes. Please use OMIM, human phenotype ontology and genecards web sites.
Being an expert in microsoft programs such as power point, excel and word.
Drawing alghoritms for variant intepretations.
Routine practice, you will follow the SOPs of the company.
Share about your experience looking for jobs: how many applications have you done till you got one? How did you feel in those days? How did opportunities show up for you? Then, please share more about your interview experience and application process for your most recent job. This section is for students to udnerstand that no one lands a dream job at once (or maybe yes?) and that ending up in a job that you like really takes time.
Since genetics is a rapidly developing field of health, I talked about the latest guidlines and developments in my interview. You can follow those on twitter or instagram. At the same time, the examples I gave on how genetic information could be used in medicine were impressive. It will be beneficial for you to know how to use gnomAD, ClinVar, HGMD, ClinGen and in silico tools such as REVEL, Mutation Taster, SIFT, PolyPhen-2, Franklin, Varsome.
Most important thing is to know ACMG variant classification in expert level. For watch these videos.
During my job search, I have learned that applying to multiple jobs can increase the chances of landing a job offer, but networking and leveraging personal connections can also be very effective in finding job opportunities. I reached out to people in my network. I talked to friends, family members, former colleagues, and others who work in my field. If you mention about current update guidelines at your interview, your chance will increase.
Draw on the information in the job description and write a cover letter that frames you as the perfect candidate. Keep your sentences concise but impactful. Include as much relevant information as you can efficiently fit into a page’s worth of paragraphs. If the employer likes what they read, they will use the interview process to learn more about the goals or skills you mentioned in your cover letter.
In conclusion, state you want to work as long as possible and be eager to learn new developments in genetic area, forwhy medical genetics is super new field.